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Nuclear erythroid 2-related factor 2-antioxidative response element signaling pathway in motor cortex and spinal cord in amyotrophic lateral sclerosis

Discussion The BBB poses a significant impediment to drug delivery, with over 98% of pharmaceutical agents unable to efficiently traverse it, thereby diminishing their therapeutic efficacy in treating various neurological disorders, including neurodegenerative diseases 35

However, copper peptides, particularly GHK-Cu, have gained serious attention in recent years due to their regenerative potential

& Townes, T

Shekarriz B, Lu HF, Stoller ML

10.15252/emmm.201707661 Summary Keywords free radical scavenging, chelation therapy, oxidative stress, semi-synthetic antioxidants, synthetic antioxidants Citation Tauchen J, Huml L, Jurek M, Regenstein JM and Ozogul F (2025) Synthetic and semi-synthetic antioxidants in medicine and food industry: a review